Cholesterol Lipid Metabolism

Whole grains are known to be good for cardiovascular health. High rye diet has on its own been connected to decreased risk of myocardial infarction. The reason behind these effects most likely lies in lipid metabolism and changes in it after consuming a high whole grain, for example rye, diet.

Both animal and clinical intervention studies have shown that high rye intake may have a positive impact on blood cholesterol levels compared to high-wheat diet even though not all studies on subject support this view. Rye may as well have beneficial effects on other serum lipids when compared to high fibre diet without rye.

Rye's cholesterol-lowering effect is thought to be mediated through the ability of water-soluble, viscose fiber to bind bile acids in the small intestine, and the bile acids are then excreted in the feces. Also, animal studies suggest that high-fiber rye diet-induced effects on plasma HDL/LDL content are partially ascribed to effects on liver cholesterol metabolism and that the hepatic phospholipase pathways of phosphatidylcholine breakdown are affected by the high-fiber rye diet.

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Leinonen KS, Poutanen KS, Mykkänen HM. (2000). Rye bread decreases serum total and LDL cholesterol in men with moderately elevated serum cholesterol. J Nutr 130:164-70.

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